The Gillberg Neuropsychiatry Centre will be hosting its 5th Birgit Olsson Lecture 18th November 2015.
Joseph Biederman, world expert in ADHD will be giving his lecture on "Current Concepts in the Neurobiology of ADHD Across the Lifecycle".
Attention-deficit hyperactivity disorder (ADHD) is a neurobiological disorder characterised by symptoms of inattention, impulsivity, and hyperactivity estimated to affect up to 10% of children and 5% of adults worldwide. Its presence confers high levels of impairment and dysfunction to affected individuals, adversely impacting all aspects of life including academic achievement, interpersonal relationships, family functioning, legal problems and addictions, among others. Twin, adoption, and molecular genetic studies show ADHD to be highly heritable, and other findings have recorded prenatal exposure to nicotine and psychosocial adversity as predisposing risk factors. Several mutations in genes that affect dopaminergic regulation have been consistently associated with ADHD. Converging evidence from animal and human studies implicates the dysregulation of frontal-subcortical-cerebellar catecholaminergic circuits in the pathophysiology of ADHD, and molecular imaging studies suggest that abnormalities of the dopamine transporter lead to impaired neurotransmission. Studies during the past decade have documented high levels of psychiatric and cognitive comorbidity in ADHD including antisocial, mood and anxiety disorders as well as learning disability and executive function deficits.
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