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Gudrun Nygren is currently working as a chief physician at the Specialist centre for children and adolescents at Angered Hospital. Her efforts include leading the three-year project “Hjällbo Collaboration Small Children”, which was started in 2013 with support from the Swedish Inheritance Fund. The aim has been to create a model with a single team for both examination and intervention for small children with autism and other developmental abnormalities, available locally at a family care centre in a multicultural borough, in this case Angered. The model has shown health economic gains such as; increased chance of reaching small children in need of examination and their families, continuity in the examination process, and individually planned intervention measures in close collaboration with parents and preschool. The operation based around a local multi-professional team will be made permanent as of 2017. Their work will be followed up with research studies.



Pilorge, M., Fassier, C., Le Corronc, H., Potey, A., Bai, J., De Gois, S., ... Betancur, C. (2016). Genetic and functional analyses demonstrate a role for abnormal glycinergic signaling in autism. Molecular Psychiatry, 21, 936-945.


Landgren, M., Fernell, E., Kopp, S., Johnson, M., Eriksson, M., Lindström, K., ... Lövoll, T. (2015). [In with updated medical knowledge when ADHD is managed]. Läkartidningen, 112.

Tabet, A.C., Verloes, A., Pilorge, M., Delaby, E., Delorme, R., Nygren, G., ... Betancur, C. (2015). Complex nature of apparently balanced chromosomal rearrangements in patients with autism spectrum disorder. Molecular Autism, 6, 19.


Scheid, I., Maruani, A., Huguet, G., Leblond, C.S., Nygren, G., Anckarsäter, H., ... Delorme, R. (2013). Heterozygous FA2H mutations in autism spectrum disorders. BMC Medical Genetics, 14, 124.


Anney, R., Klei, L., Pinto, D., Almeida, J., Bacchelli, E., Baird, G., … Devlin, B. (2012). Individual common variants exert weak effects on the risk for autism spectrum disorders. Human Molecular Genetics, 21, 4781-4792.

Casey, J.P., Magalhaes, T., Conroy, J.M., Regan, R., Shah, N., Anney, R., … Ennis, S. (2012). A novel approach of homozygous haplotype sharing identifies candidate genes in autism spectrum disorder. Human Genetics, 131, 565-579.

Leblond, C.S., Heinrich, J., Delorme, R., Proepper, C., Betancur, C., Huguet, G., … Bourgeron, T. (2012). Genetic and functional analyses of SHANK2 mutations suggest a multiple hit model of autism spectrum disorders. PLoS Genetics, 8, e1002521.

Nygren, G. (2012). Screening and Diagnosis of Autism Spectrum Disorders. (Doctoral Thesis). University of Gothenburg, Gothenburg.

Nygren, G., Sandberg, E., Gillstedt, F., Ekeroth, G., Arvidsson, T., & Gillberg, C. (2012). A new screening programme for autism in a general population of Swedish toddlers. Research in Developmental Disabilities, 33, 1200-1210.

Nygren, G., Cederlund, M., Sandberg, E., Gillstedt, F., Arvidsson, T., Carina Gillberg, I., … Gillberg, C. (2012). The prevalence of autism spectrum disorders in toddlers: a population study of 2-year-old Swedish children. Journal of Autism and Developmental Disorders, 42, 1491-1497.


Anney, R.J., Kenny, E.M., O'Dushlaine, C., Yaspan, B.L., Parkhomenka, E., Buxbaum, J.D., ... Gallagher L. (2011). Gene-ontology enrichment analysis in two independent family-based samples highlights biologically plausible processes for autism spectrum disorders. European Journal of Human Genetics, 19, 1082-1089.

Chaste, P., Clement, N., Botros, H.G., Guillaume, J.L., Konyukh, M., Pagan, C., … Bourgeron, T. (2011). Genetic variations of the melatonin pathway in patients with attention-deficit and hyperactivity disorders. Journal of Pineal Research, 51, 394-399.

Konyukh, M., Delorme, R., Chaste, P., Leblond, C., Lèmiere, N., Nygren, G., … Bourgeron, T. (2011). Variations of the candidate SEZ6L2 gene on Chromosome 16p11.2 in patients with autism spectrum disorders and in human populations. PLoS One, 6, e17289.


Anney, R., Klei, L., Pinto, D., Regan, R., Conroy, J., Magalhaes, T.R., … Hallmayer, J. (2010). A genome-wide scan for common alleles affecting risk for autism. Human Molecular Genetics, 19, 4072-4082.

Chaste, P., Clement, N., Mercati, O., Guillaume, J.L., Delorme, R., Botros, H. G., … Bourgeron, T. (2010). Identification of pathway-biased and deleterious melatonin receptor mutants in autism spectrum disorders and in the general population. PLoS One, 5, e11495.

Delorme, R., Betancur, C., Scheid, I., Anckarsäter, H., Chaste, P., Jamain, S., … Bourgeron, T. (2010). Mutation screening of NOS1AP gene in a large sample of psychiatric patients and controls. BMC Medical Genetics, 11,108.

Nygren, G., Sandberg, E., Arvidsson, T., & Gillberg, C. (2010). [The unique role of child health services--early recognition of autism. Experiences with new routines in child health care in Gothenburg]. Läkartidningen, 107, 2314-2318.

Pinto, D., Pagnamenta, A.T., Klei, L., Anney, R., Merico, D., Regan, R., …. Betancur, C. (2010). Functional impact of global rare copy number variation in autism spectrum disorders. Nature, 466, 368-372.


Depienne, C., Moreno-De-Luca, D., Heron, D., Bouteiller, D., Gennetier, A., Delorme, R., … Betancur, C. (2009). Screening for genomic rearrangements and methylation abnormalities of the 15q11-q13 region in autism spectrum disorders. Biological Psychiatry, 66, 349-359.

Gong, X., Delorme, R., Fauchereau, F., Durand, C.M., Chaste, P., Betancur, C., … Bourgeron, T. (2009). An investigation of ribosomal protein L10 gene in autism spectrum disorders. BMC Medical Genetics, 10, 7.

Henningsson, S., Jonsson, L., Ljunggren, E., Westberg, L., Gillberg, C., Råstam, M., … Melke, J. (2009). Possible association between the androgen receptor gene and autism spectrum disorder. Psychoneuroendocrinology, 34, 752-761.

Nygren, G., Hagberg, B., Billstedt, E., Skoglund, A., Gillberg, C., & Johansson, M. (2009). The Swedish version of the Diagnostic Interview for Social and Communication Disorders (DISCO-10). Psychometric properties. Journal of Autism and Developmental Disorders, 39, 730-741.

Orekhova, E.V., Stroganova, T. A., Prokofiev, A.O., Nygren, G., Gillberg, C., & Elam, M. (2009). The right hemisphere fails to respond to temporal novelty in autism: evidence from an ERP study. Clinical Neurophysiology, 120, 520-529.


Gong, X., Bacchelli, E., Blasi, F., Toma, C., Betancur, C., Chaste, P., … Bourgeron, T. (2008). Analysis of X chromosome inactivation in autism spectrum disorders. American Journal of Medical Genetics. Part B, Neuropsychiatric Genetics, 147B, 830-835.

Melke, J., Goubran Botros, H., Chaste, P., Betancur, C., Nygren, G., Anckarsäter, H., … Bourgeron, T. (2008). Abnormal melatonin synthesis in autism spectrum disorders. Molecular Psychiatry, 13, 90-98.

Orekhova, E.V., Stroganova, T.A., Prokofyev, A.O., Nygren, G., Gillberg, C., & Elam, M. (2008). Sensory gating in young children with autism: relation to age, IQ, and EEG gamma oscillations. Neuroscience Letters, 434, 218-223.


Buxbaum, J.D., Cai, G., Chaste, P., Nygren, G., Goldsmith, J., Reichert, J., … Betancur, C. (2007). Mutation screening of the PTEN gene in patients with autism spectrum disorders and macrocephaly. American Journal of Medical Genetics. Part B, Neuropsychiatric Genetics, 144B, 484-491.

Buxbaum, J.D., Cai, G., Nygren, G., Chaste, P., Delorme, R., Goldsmith, J., … Betancur, C. (2007). Mutation analysis of the NSD1 gene in patients with autism spectrum disorders and macrocephaly. BMC Medical Genetics, 8, 68.

Chaste, P., Nygren, G., Anckarsater, H., Rastam, M., Coleman, M., Leboyer, M., . . . Betancur, C. (2007). Mutation screening of the ARX gene in patients with autism. American Journal of Medical Genetics. Part B, Neuropsychiatric Genetics, 144B, 228-230.

Durand, C.M., Betancur, C., Boeckers, T.M., Bockmann, J., Chaste, P., Fauchereau, F., … Bourgeron, T. (2007). Mutations in the gene encoding the synaptic scaffolding protein SHANK3 are associated with autism spectrum disorders. Nature Genetics, 39, 25-27.

Orekhova, E.V., Stroganova, T.A., Nygren, G., Tsetlin, M.M., Posikera, I.N., Gillberg, C., & Elam, M. (2007). Excess of high frequency electroencephalogram oscillations in boys with autism. Biological Psychiatry, 62, 1022-1029.

Stroganova, T.A., Nygren, G., Tsetlin, M.M., Posikera, I.N., Gillberg, C., Elam, M., & Orekhova, E.V. (2007). Abnormal EEG lateralization in boys with autism. Clinical Neurophysiology, 118, 1842-1854.


Delorme, R., Durand, C. M., Betancur, C., Wagner, M., Ruhrmann, S., Grabe, H.J., … Malafosse, A. (2006). No human tryptophan hydroxylase-2 gene R441H mutation in a large cohort of psychiatric patients and control subjects. Biological Psychiatry, 60, 202-203

Durand, C.M., Kappeler, C., Betancur, C., Delorme, R., Quach, H., Goubran-Botros, H., … Bourgeron, T. (2006). Expression and genetic variability of PCDH11Y, a gene specific to Homo sapiens and candidate for susceptibility to psychiatric disorders. American Journal of Medical Genetics. Part B, Neuropsychiatric Genetics, 141B, 67-70.

Miniscalco, C., Nygren, G., Hagberg, B., Kadesjö, B., & Gillberg, C. (2006). Neuropsychiatric and neurodevelopmental outcome of children at age 6 and 7 years who screened positive for language problems at 30 months. Developmental Medicine and Child Neurology, 48, 361-366.


Delorme, R., Betancur, C., Wagner, M., Krebs, M.O., Gorwood, P., Pearl, P., . . . Bourgeron, T. (2005). Support for the association between the rare functional variant I425V of the serotonin transporter gene and susceptibility to obsessive compulsive disorder. Molecular Psychiatry, 10, 1059-1061.





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Gudrun Nygren

Page Manager: Anna Spyrou|Last update: 12/21/2016

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