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Profil

För närvarande arbetar Gudrun Nygren som överläkare vid Specialistcentrum för barn och unga vid Angereds närsjukhus. Hon har bl.a. lett ett ett treårigt projekt ”HjällboSamverkan Små barn” som startades 2013 med stöd från Allmänna Arvsfonden. Syftet har varit att utarbeta en modell med ett team för både utredning och insatser för små barn med autism och andra utvecklingsavvikelser lokalt på en familjecentral i den mångkulturella stadsdelen. Modellen har visat på hälsoekonomiska vinster såsom; ökad möjlighet att nå små barn i behov av utredning och deras familjer samt kontinuitet i utredning och individuellt planerade insatser i nära samverkan med föräldrar och förskola . Verksamheten med ett lokalt multiprofessionellt team permanentas från 2017. Arbetet följs med forskningsstudier.

Publikationer

2016

Pilorge, M., Fassier, C., Le Corronc, H., Potey, A., Bai, J., De Gois, S., ... Betancur, C. (2016). Genetic and functional analyses demonstrate a role for abnormal glycinergic signaling in autism. Molecular Psychiatry, 21, 936-945.

2015

Landgren, M., Fernell, E., Kopp, S., Johnson, M., Eriksson, M., Lindström, K., ... Lövoll, T. (2015). [In with updated medical knowledge when ADHD is managed]. Läkartidningen, 112.

Tabet, A.C., Verloes, A., Pilorge, M., Delaby, E., Delorme, R., Nygren, G., ... Betancur, C. (2015). Complex nature of apparently balanced chromosomal rearrangements in patients with autism spectrum disorder. Molecular Autism, 6, 19.

2013

Scheid, I., Maruani, A., Huguet, G., Leblond, C.S., Nygren, G., Anckarsäter, H., ... Delorme, R. (2013). Heterozygous FA2H mutations in autism spectrum disorders. BMC Medical Genetics, 14, 124.

2012

Anney, R., Klei, L., Pinto, D., Almeida, J., Bacchelli, E., Baird, G., … Devlin, B. (2012). Individual common variants exert weak effects on the risk for autism spectrum disorders. Human Molecular Genetics, 21, 4781-4792.

Casey, J.P., Magalhaes, T., Conroy, J.M., Regan, R., Shah, N., Anney, R., … Ennis, S. (2012). A novel approach of homozygous haplotype sharing identifies candidate genes in autism spectrum disorder. Human Genetics, 131, 565-579.

Leblond, C.S., Heinrich, J., Delorme, R., Proepper, C., Betancur, C., Huguet, G., … Bourgeron, T. (2012). Genetic and functional analyses of SHANK2 mutations suggest a multiple hit model of autism spectrum disorders. PLoS Genetics, 8, e1002521.

Nygren, G. (2012). Screening and Diagnosis of Autism Spectrum Disorders. (Doctoral Thesis). University of Gothenburg, Gothenburg.

Nygren, G., Sandberg, E., Gillstedt, F., Ekeroth, G., Arvidsson, T., & Gillberg, C. (2012). A new screening programme for autism in a general population of Swedish toddlers. Research in Developmental Disabilities, 33, 1200-1210.

Nygren, G., Cederlund, M., Sandberg, E., Gillstedt, F., Arvidsson, T., Carina Gillberg, I., … Gillberg, C. (2012). The prevalence of autism spectrum disorders in toddlers: a population study of 2-year-old Swedish children. Journal of Autism and Developmental Disorders, 42, 1491-1497.

2011

Anney, R.J., Kenny, E.M., O'Dushlaine, C., Yaspan, B.L., Parkhomenka, E., Buxbaum, J.D., ... Gallagher L. (2011). Gene-ontology enrichment analysis in two independent family-based samples highlights biologically plausible processes for autism spectrum disorders. European Journal of Human Genetics, 19, 1082-1089.

Chaste, P., Clement, N., Botros, H.G., Guillaume, J.L., Konyukh, M., Pagan, C., … Bourgeron, T. (2011). Genetic variations of the melatonin pathway in patients with attention-deficit and hyperactivity disorders. Journal of Pineal Research, 51, 394-399.

Konyukh, M., Delorme, R., Chaste, P., Leblond, C., Lèmiere, N., Nygren, G., … Bourgeron, T. (2011). Variations of the candidate SEZ6L2 gene on Chromosome 16p11.2 in patients with autism spectrum disorders and in human populations. PLoS One, 6, e17289.
 

2010

Anney, R., Klei, L., Pinto, D., Regan, R., Conroy, J., Magalhaes, T.R., … Hallmayer, J. (2010). A genome-wide scan for common alleles affecting risk for autism. Human Molecular Genetics, 19, 4072-4082.

Chaste, P., Clement, N., Mercati, O., Guillaume, J.L., Delorme, R., Botros, H. G., … Bourgeron, T. (2010). Identification of pathway-biased and deleterious melatonin receptor mutants in autism spectrum disorders and in the general population. PLoS One, 5, e11495.

Delorme, R., Betancur, C., Scheid, I., Anckarsäter, H., Chaste, P., Jamain, S., … Bourgeron, T. (2010). Mutation screening of NOS1AP gene in a large sample of psychiatric patients and controls. BMC Medical Genetics, 11,108.

Nygren, G., Sandberg, E., Arvidsson, T., & Gillberg, C. (2010). [The unique role of child health services--early recognition of autism. Experiences with new routines in child health care in Gothenburg]. Läkartidningen, 107, 2314-2318.

Pinto, D., Pagnamenta, A.T., Klei, L., Anney, R., Merico, D., Regan, R., …. Betancur, C. (2010). Functional impact of global rare copy number variation in autism spectrum disorders. Nature, 466, 368-372.

2009

Depienne, C., Moreno-De-Luca, D., Heron, D., Bouteiller, D., Gennetier, A., Delorme, R., … Betancur, C. (2009). Screening for genomic rearrangements and methylation abnormalities of the 15q11-q13 region in autism spectrum disorders. Biological Psychiatry, 66, 349-359.

Gong, X., Delorme, R., Fauchereau, F., Durand, C.M., Chaste, P., Betancur, C., … Bourgeron, T. (2009). An investigation of ribosomal protein L10 gene in autism spectrum disorders. BMC Medical Genetics, 10, 7.

Henningsson, S., Jonsson, L., Ljunggren, E., Westberg, L., Gillberg, C., Råstam, M., … Melke, J. (2009). Possible association between the androgen receptor gene and autism spectrum disorder. Psychoneuroendocrinology, 34, 752-761.

Nygren, G., Hagberg, B., Billstedt, E., Skoglund, A., Gillberg, C., & Johansson, M. (2009). The Swedish version of the Diagnostic Interview for Social and Communication Disorders (DISCO-10). Psychometric properties. Journal of Autism and Developmental Disorders, 39, 730-741.

Orekhova, E.V., Stroganova, T. A., Prokofiev, A.O., Nygren, G., Gillberg, C., & Elam, M. (2009). The right hemisphere fails to respond to temporal novelty in autism: evidence from an ERP study. Clinical Neurophysiology, 120, 520-529.

2008

Gong, X., Bacchelli, E., Blasi, F., Toma, C., Betancur, C., Chaste, P., … Bourgeron, T. (2008). Analysis of X chromosome inactivation in autism spectrum disorders. American Journal of Medical Genetics. Part B, Neuropsychiatric Genetics, 147B, 830-835.

Melke, J., Goubran Botros, H., Chaste, P., Betancur, C., Nygren, G., Anckarsäter, H., … Bourgeron, T. (2008). Abnormal melatonin synthesis in autism spectrum disorders. Molecular Psychiatry, 13, 90-98.

Orekhova, E.V., Stroganova, T.A., Prokofyev, A.O., Nygren, G., Gillberg, C., & Elam, M. (2008). Sensory gating in young children with autism: relation to age, IQ, and EEG gamma oscillations. Neuroscience Letters, 434, 218-223.

2007

Buxbaum, J.D., Cai, G., Chaste, P., Nygren, G., Goldsmith, J., Reichert, J., … Betancur, C. (2007). Mutation screening of the PTEN gene in patients with autism spectrum disorders and macrocephaly. American Journal of Medical Genetics. Part B, Neuropsychiatric Genetics, 144B, 484-491.

Buxbaum, J.D., Cai, G., Nygren, G., Chaste, P., Delorme, R., Goldsmith, J., … Betancur, C. (2007). Mutation analysis of the NSD1 gene in patients with autism spectrum disorders and macrocephaly. BMC Medical Genetics, 8, 68.

Chaste, P., Nygren, G., Anckarsater, H., Rastam, M., Coleman, M., Leboyer, M., . . . Betancur, C. (2007). Mutation screening of the ARX gene in patients with autism. American Journal of Medical Genetics. Part B, Neuropsychiatric Genetics, 144B, 228-230.

Durand, C.M., Betancur, C., Boeckers, T.M., Bockmann, J., Chaste, P., Fauchereau, F., … Bourgeron, T. (2007). Mutations in the gene encoding the synaptic scaffolding protein SHANK3 are associated with autism spectrum disorders. Nature Genetics, 39, 25-27.

Orekhova, E.V., Stroganova, T.A., Nygren, G., Tsetlin, M.M., Posikera, I.N., Gillberg, C., & Elam, M. (2007). Excess of high frequency electroencephalogram oscillations in boys with autism. Biological Psychiatry, 62, 1022-1029.

Stroganova, T.A., Nygren, G., Tsetlin, M.M., Posikera, I.N., Gillberg, C., Elam, M., & Orekhova, E.V. (2007). Abnormal EEG lateralization in boys with autism. Clinical Neurophysiology, 118, 1842-1854.

2006

Delorme, R., Durand, C. M., Betancur, C., Wagner, M., Ruhrmann, S., Grabe, H.J., … Malafosse, A. (2006). No human tryptophan hydroxylase-2 gene R441H mutation in a large cohort of psychiatric patients and control subjects. Biological Psychiatry, 60, 202-203

Durand, C.M., Kappeler, C., Betancur, C., Delorme, R., Quach, H., Goubran-Botros, H., … Bourgeron, T. (2006). Expression and genetic variability of PCDH11Y, a gene specific to Homo sapiens and candidate for susceptibility to psychiatric disorders. American Journal of Medical Genetics. Part B, Neuropsychiatric Genetics, 141B, 67-70.

Miniscalco, C., Nygren, G., Hagberg, B., Kadesjö, B., & Gillberg, C. (2006). Neuropsychiatric and neurodevelopmental outcome of children at age 6 and 7 years who screened positive for language problems at 30 months. Developmental Medicine and Child Neurology, 48, 361-366.

2005

Delorme, R., Betancur, C., Wagner, M., Krebs, M.O., Gorwood, P., Pearl, P., . . . Bourgeron, T. (2005). Support for the association between the rare functional variant I425V of the serotonin transporter gene and susceptibility to obsessive compulsive disorder. Molecular Psychiatry, 10, 1059-1061.

 

 

Kontaktinformation

Gudrun Nygren

Sidansvarig: Anna Spyrou|Sidan uppdaterades: 2016-12-21
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